![]() Although several variables were associated with the development of sick sinus syndrome (e.g, higher body mass index, hypertension, prior cardiovascular event), advancing age was the most significant risk factor for sick sinus syndrome (hazard ratio 1.73 for each additional 5 years of age) 6). Only a few epidemiologic studies have been published.Ī pooled analysis of 20,572 patients from 2 large epidemiology studies (the Atherosclerosis Risk in Communities and Cardiovascular Health Study trials) who were followed for an average of 17 years, 291 incident cases of sick sinus syndrome were noted, yielding an incidence rate of 0.8 cases per 1000 person-years 5). ![]() Symptomatic patients are generally older, in seventh or eighth decade of life, with frequent comorbidities. ![]() Due to its relationship with advanced age, sick sinus syndrome is more prevalent in countries where citizens have a longer life expectancy. It is estimated that the incidence of sick sinus syndrome in the United States is approximately 1 in 600 cardiac patients older than 65 years 4). The epidemiology of sick sinus syndrome is difficult to study, given its nature and varying manifestations, including nonspecific symptoms and electrocardiographic (ECG) findings.
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